Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 SARS-CoV-2. Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
NMR Observation of Sulfhydryl Signals in SARS-CoV-2 Main Protease Aids Structural StudiesArticle Published on 2022-10-062022-11-15 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL pro AID aliphatic AlphaFold-Multimers amide antiviral drug target backbone binding Combination competitive binding drug design effective experiment High-resolution homodimeric identify Interaction Ligand ligand binding. ligands M pro Mpro/3CLPro N-terminal NMR NMR spectroscopy peptides protease Protein protons remained reveal SARS-CoV-2 sequence signal solvent sulfhydryl thiol group variant [DOI] 10.1002/cbic.202200471 PMC 바로가기
NMR spectroscopy spotlighting immunogenicity induced by COVID-19 vaccination to mitigate future health concernsReview article Published on 2022-08-222022-10-05 Journal: Current Research in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] affected Analysis approach BALF biological samples Biomarker Blood breast milk Bronchoalveolar-lavage fluid cerebrospinal fluid chemometrics complex COVID-19 COVID-19 vaccination CSF described detect disease examined example explain Health immunogenicity IMPROVE management metabolome mitigate molecular NMR NMR spectroscopy nuclear Nuclear magnetic resonance spectroscopy PCA Saliva Semen statistical the disease Treatment Urine vaccination Vaccine [DOI] 10.1016/j.crimmu.2022.08.006 [Article Type] Review article
NMR Reveals Specific Tracts within the Intrinsically Disordered Regions of the SARS-CoV-2 Nucleocapsid Protein Involved in RNA EncounteringNMR은 RNA 조우에 관여하는 SARS-CoV-2 뉴클레오캡시드 단백질의 본질적으로 무질서한 영역 내의 특정 경로를 나타냅니다Article Published on 2022-07-022022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence atomic binding domain concert COVID-19 Disordered domain engage event experiments genomic RNA identify IDP information Interaction intrinsically N-terminal NMR NMR spectroscopy NTD organized primary sequence priming Protein Region Regulatory RNA SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA SARS-CoV-2. Specific the SARS-CoV-2 tract Transcription [DOI] 10.3390/biom12070929 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR ViewArticle Published on 2022-04-252023-07-08 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), [키워드] 13C-Labelling molecular recognition NMR spectroscopy SARS-CoV2 Sialic acid. [DOI] 10.1002/anie.202201432 PMC 바로가기
Purification and mass spectrometry study of Maillard reaction impurities in five acyclic nucleoside antiviral drugsResearch article Published on 2022-04-012022-10-05 Journal: Journal of pharmaceutical and biomedical analysis [Category] 치료제, [키워드] Acyclic nucleoside antiviral drugs analyzed antiviral drug antiviral drugs API compatibility Compound condition decrease Degradation drugs FIVE Impurities increase in ingredient Maillard reaction mass spectrometry mechanism Neutral NMR spectroscopy nucleoside nucleosides purified stability Structural identification was performed [DOI] 10.1016/j.jpba.2022.114637 [Article Type] Research article
Are the Follicular Fluid Characteristics of Recovered Coronavirus Disease 2019 Patients Different From Those of Vaccinated Women Approaching in vitro Fertilization?Physiology Published on 2022-02-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Ala Analysis anti SARS-CoV-2 immunoglobulins antibody carried collected Combination control group coronavirus disease Covid patients COVID-19 dismutase evaluate FIVE Follicular fluid healthy healthy controls in vitro induce inflammatory proteins interleukin-6 Lipid metabolic effect metabolite metabolomic analysis metabolomics Necrosis nine NMR NMR spectroscopy Oocyte outcome participant pilot study Pro proinflammatory markers radical scavenger recovered recovered COVID-19 patient Recovered COVID-19 patients SARS-CoV-2 SARS-COV-2 infection selected significantly lower TNF-α TNFα trimethylamine vaccination was performed western blotting analysis women [DOI] 10.3389/fphys.2022.840109 PMC 바로가기 [Article Type] Physiology
1 H, 13 C and 15 N chemical shift assignment of the stem-loops 5b + c from the 5′-UTR of SARS-CoV-2Article Published on 2022-02-182022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] 5′-UTR 5′-untranslated region 5′-UTR antiviral drug target caused conserved COVID-19 COVID19-NMR elements feature genomic information involved NMR spectroscopy nucleotide pandemic positive Regulation Respiratory disease RNA RNA genome SARS-CoV-2 sequence SL5b SL5b + c SL5c Solution NMR spectroscopy supplementary material Support the Betacoronavirus the SARS-CoV-2 translation viral replication virus [DOI] 10.1007/s12104-021-10053-4 PMC 바로가기 [Article Type] Article
1 H, 13 C and 15 N chemical shift assignment of the stem-loops 5b + c from the 5′-UTR of SARS-CoV-2Article Published on 2022-02-182022-10-27 Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] 5′-UTR 5′-untranslated region 5′-UTR antiviral drug target caused conserved COVID-19 COVID19-NMR elements feature genomic information involved NMR spectroscopy nucleotide pandemic positive Regulation Respiratory disease RNA RNA genome SARS-CoV-2 sequence SL5b SL5b + c SL5c Solution NMR spectroscopy supplementary material Support the Betacoronavirus the SARS-CoV-2 translation viral replication virus [DOI] 10.1007/s12104-021-10053-4 PMC 바로가기 [Article Type] Article
The Extended Hadamard Transform: Sensitivity-Enhanced NMR Experiments Among Labile and Non-Labile 1 Hs of SARS-CoV-2-derived RNAsArticle Published on 2022-02-162023-07-07 Journal: Chemphyschem : a European journal of chemical physics and physical [Category] COVID19(2023년), [키워드] Hadamard encoding NMR spectroscopy NOESY nucleic acids. SARS-CoV-2 genome [DOI] 10.1002/cphc.202100704 PMC 바로가기